The YUMAB® platform can be used for the engineering of already existing antibodies that were generated externally. Two in-vitro evolution technologies are available for the optimization of the antibody’s affinity, stability, specificity or selectivity:
- in-vitro evolution by YUlight shuffling
- in-vitro evolution by mutagenesis
Additionally, in-silico analysis can be applied to identify and optimize antibodies with the best developability score.
- in-silico analysis and optimization